Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function
نویسندگان
چکیده
منابع مشابه
Alteration of synaptic connectivity of oligodendrocyte precursor cells following demyelination
Oligodendrocyte precursor cells (OPCs) are a major source of remyelinating oligodendrocytes in demyelinating diseases such as Multiple Sclerosis (MS). While OPCs are innervated by unmyelinated axons in the normal brain, the fate of such synaptic contacts after demyelination is still unclear. By combining electrophysiology and immunostainings in different transgenic mice expressing fluorescent r...
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Background: Oligodendrocyte cell death is among the important features of spinal cord injury, which appears within 15 min and occurs intensely for 4 h after injury, in the rat spinal contusion model. Accordingly, the number of oligodendrocytes progressively reduced within 24 h after injury. Administration of oligodendrocyte-like cells (OLCs) into the lesion area is one of the approaches to coun...
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We previously examined the effect of brain microvascular endothelial cell (MVEC) transplantation on rat white matter infarction, and found that MVEC transplantation promoted remyelination of demyelinated axons in the infarct region and reduced apoptotic death of oligodendrocyte precursor cells (OPCs). We also found that the conditioned medium (CM) from cultured MVECs inhibited apoptosis of cult...
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Our interest in developmental timing began with a surprising experimental result obtained by Erika Abney, an immunologist who joined our group in the late 1970s. We had earlier defined a set of cell-type-specific markers that allowed us to distinguish the major types of glial cells found in suspensions and cultures of rat central nervous system (CNS) cells: astrocytes, which are heterogeneous a...
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Address correspondence to Mark Noble, Huntsman Cancer Institute, Rm. 4280, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112. Tel.: (801) 585-7167. Fax: (801) 585-7120. E-mail: [email protected] The physiological demands made upon precursor cell populations during different developmental epochs can be remarkably divergent, particularly in tissues that do not...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2021
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.344218.120